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Convergent Functional Genomics

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Pathways and Mechanisms


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(PDF file)

Niculescu SASS: Simplified Affective State Scale
(PDF file)

Niculescu Convergent Functional Information for Suicidality Scale (CFI-S)
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Semantic Web Primer (PDF file)


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Pathways and Mechanisms


D.F. Levey, H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu. Genetic Risk Prediction and Neurobiological Understanding of Alcoholism. Translational Psychiatry 2014 Epub May 20.

Ingenuity, KEGG, and GeneGo Pathway Analyses of top candidate genes for alcoholism.


Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry 2013 Epub August 20.

Ingenuity and KEGG Pathway Analyses of top candidate genes for suicidality.



Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O'Donovan M, Niculescu AB. Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction. Molecular Psychiatry 2012 Epub May 15.

Ingenuity Pathway Analysis of top candidate genes for schizophernia.

A comprehensive model for schizophrenia pathophysiology.


Anxiety Disorders

Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M, Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA,
Niculescu AB. Convergent Functional Genomics of Anxiety Disorders: Translational Identification of Genes,
Biomarkers, Pathways and Mechanisms. Translational Psychiatry. Epub 2011 May 24.

Top biological pathways for anxiety in different brain regions. Overlap between brain regions, and with the blood.

Bipolar Disorder

Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB. Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). Epub 2010 April 9.

Ingenuity Pathway Analysis of top candidate genes for Bipolar Disorder


SM Kurian, H Le-Niculescu, SD Patel, D Bertram, J Davis, C Dike, N Yehyawi, P Lysaker, J Dustin, M Caligiuri, J Lohr, DK Lahiri, JI Nurnberger Jr, SV Faraone, MA Geyer, MT Tsuang, NJ Schork, DR Salomon and AB Niculescu. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry. 2009 Epub Nov 24.

Ingenuity Pathway Analysis of top candidate biomarkers

Psychosis: disconnection and de-differentiation

Bipolar Disorder

H. Le-Niculescu, S.D. Patel, M. Bhat, R. Kuczenski, S.V. Faraone, M.T. Tsuang, F.J. McMahon, N.J. Schork, J.I. Nurnberger Jr., and A.B. Niculescu III. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181

Ingenuity Pathway Analysis of top candidate genes

A comprehensive model for bipolar disorder pathophysiology.