Laboratory of Neurophenomics | Selected Publications

Niculescu AB, Le-Niculescu H. Dissecting Suicidality Using a Combined Genomic and Clinical Approach. Neuropsychopharmacology 2017 42, 360; doi:10.1038/npp.2016.228. PMID: 27909331

pdf file (62 KB)

Rangaraju S, Levey DF, Nho N, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, and Niculescu AB. Mood, Stress and Longevity: Convergence on ANK3. Molecular Psychiatry. 2016 Aug;21(8):1037-49. doi: 10.1038/mp.2016.65. Epub 2016 May 24. PMID: 27217151

pdf file (3.61 MB)

Levey DF, Niculescu EM, Le-Niculescu H, Dainton HD, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry. 2016 Jun;21(6):768-85. doi: 10.1038/mp.2016.31. Epub 2016 Apr 5. PMID: 27046645

pdf file (4.11 MB)

Niculescu AB. A brief proposal for improving clinical trials. Molecular Psychiatry. 2016 Jun;21(6):736-7. doi: 10.1038/mp.2016.42. Epub 2016 Mar 29. PMID: 27021813

pdf file (83 KB)

Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, Petrascheck M. Elife. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. eLife 2015 Dec 1;4. pii: e08833. doi: 10.7554 PMID: 26623667

pdf file (2.89 MB)

Niculescu AB , Levey DF, Phalen PL, Le-Niculescu H, Dainton HD ,Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Molecular Psychiatry 2015 20: 1266–1285; doi:10.1038/mp.2015.112; Epub August 18 PMID: 26283638

pdf file (7 MB)

Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD, Niculescu AB, Petrascheck M. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell. 2015 Dec;14(6):971-81. doi: 10.1111/acel.12379. Epub 2015 Aug 8
PMID: 26255886

pdf file (1.06 MB)

Swaminathan S, Koller DL, Foroud T, Edenberg HJ, Xuei X, Niculescu AB 3rd; Bipolar Genome Study (BiGS) Consortium,, Nurnberger JI Jr. J. Characteristics of Bipolar I patients grouped by externalizing disorders. Affect Disord. 2015 Jun 1;178:206-14. doi: 10.1016/j.jad.2015.03.011. Epub 2015 Mar 14. PMID: 25827505

pdf file (325 KB)

Nho K, Ramanan VK, Horgusluoglu E, Kim S, Inlow MH, Risacher SL, McDonald BC, Farlow MR, Foroud TM, Gao S, Callahan CM, Hendrie HC, Niculescu AB, Saykin AJ; Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults. Alzheimer’s Disease Neuroimaging Initiative (ADNI). J Alzheimers Dis. 2015;45(4):1197-206. doi: 10.3233/JAD-148009. PMID: 25690665

pdf file (266 KB)

Niculescu AB, Levey DF, Le-Niculescu H, Niculescu E, Kurian SM, Salomon, D. Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Molecular Psychiatry2015 Mar;20(3):286-8. doi: 10.1038/mp.2014.180. Epub 2015 Jan 13. PMID: 25582618

pdf file (720 KB)

Levey DF., H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu. Genetic Risk Prediction and Neurobiological Understanding of Alcoholism. Translational Psychiatry 2014 May 20;4:e391. doi: 10.1038/tp.2014.29. 2014 Epub May 20. PMID: 24844177

pdf file (2.54 MB)

Niculescu AB. DISCovery in psychiatric genetics. Molecular Psychiatry 2014 Feb;19(2):145. doi: 10.1038/mp.2013.176. Epub 2013 Dec 17. PMID: 24342993

pdf file (59 KB)

Niculescu AB. Convergent functional genomics of stem cell-derived cells. Translational Psychiatry. 2013 Sep 10;3:e305. doi: 10.1038/tp.2013.78. PMID: 24022510

pdf file (691 KB)

Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry 2013 Dec;18(12):1249-64. doi: 10.1038/mp.2013.95. Epub 2013 Aug 20. PMID: 23958961

pdf file (3.6 MB)

Niculescu AB. Convergent Functional Genomics of Psychiatric Disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2013 Oct;162B(7):587-94. doi: 10.1002/ajmg.b.32163. 2013 Epub May 31.

pdf file (339 KB)

Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O’Donovan M, Niculescu AB. Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction. Molecular Psychiatry 2012 Sep;17(9):887-905. doi: 10.1038/mp.2012.37. Epub 2012 May 15.

pdf file (1.44 MB)

Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M , Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA and Niculescu AB.Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Translational Psychiatry 2011. Epub 2011 May 24.

pdf file (1.6 MB)

Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD , Bowker D, Gupta J, Bell R, Edenberg HJ , Tsuang MT, Kuczenski R, Geyer MA, Rodd Z, Niculescu AB. Convergent Functional Genomic Studies of Omega-3 Fatty Acids in Stress Reactivity, Bipolar Disorder and Alcoholism. Translational Psychiatry 2011. Epub 2011 April 26.

pdf file (1.07 MB)

Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger Jr JI, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR and Niculescu AB. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry 2011 February;16, 37–58. Epub 2009 Nov 24.

pdf file (1.10 MB)

Le-Niculescu H, Patel SD, Niculescu AB. Convergent Integration of Animal Model and Human Studies of
Bipolar Disorder (manic-depressive illness). Current Opinion in Pharmacology 2010, 10:594–600

pdf file (557 KB)

Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB.
Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B
(Neuropsychiatric Genetics). 2010. Jun 5;153B(4):850-77. Epub April 9.

pdf file (621 KB)

Niculescu AB, Le-Niculescu H. The P-Value Illusion: How to Improve (Psychiatric) Genetic Studies.
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2010. Jun 5;153B(4):847-9

pdf file (61 KB)

Niculescu AB, Hulvershorn L. Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri-Dimensional Approach. Psychopharm Review. 2010. 45(2): 9-16.

pdf file (281 KB)

Niculescu AB, Le-Niculescu H. Convergent Functional Genomics: What We Have Learned and Can Learn About Genes, Pathways, and Mechanisms. Neuropsychopharmacology. 2010 Jan;35(1):355-6.

pdf file (784 KB)

Caligiuri MP, Teulings HL, Dean CE, Niculescu AB 3rd, Lohr JB. Handwriting movement kinematics for
quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010
May 15;177(1-2):77-83.

pdf file (616 KB)

McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT. Evidence for genetic association of RORB with bipolar disorder. BMC Psychiatry. 2009 Nov 12;9:70.

pdf file (308 KB)

Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Human Movement Science. 2009 Oct;28(5):633-42. Epub 2009 Aug 18.

pdf file (763 KB)

Niculescu AB, Schork NJ, Salomon DR. Mindscape: A convergent perspective on life, mind, consciousness and happiness. Journal of Affective Disorders. 2010 Jun;123(1-3):1-8.

pdf file (317 KB)

Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger Jr JI, and Niculescu AB. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181.

pdf file (824 KB)

Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger Jr JI, Niculescu AB. Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics. Molecular Psychiatry. 2009 Feb;14(2):156-74. Epub 2008 Feb 26.

pdf file (259 KB)

Liu L, Foroud R, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon E, Kelsoe J, Lawson W, MacKinnon D, McInnis M, McMahon F, Murphy D, Rice J, Scheftner W, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger Jr JI. Evidence of association between brain-derived neurotrophic factor (BDNF) gene and bipolar disorder. Psychiatric Genetics. 2008 Dec;18(6):267-74.

pdf file (380 KB)

Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S , Tan J, Rodd ZA, Paulus M, Geyer M, Edenberg HJ, Glatt SJ, Faraone SV, , Nurnberger JI, Kuczenski R, Tsuang MT and Niculescu AB. Phenomic, convergent functional genomic and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2008 Mar 5;147(2):134-166.

pdf file (1 MB)

Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM, Salomon DR, Tsuang MT, Nurnberger Jr JI, Niculescu AB. Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers. Neuroscience Biobehavioral Reviews Rev. 2007;31(6):897-903. Epub 2007 Jun 3. Review.

pdf file (726 KB)

Le-Niculescu H, Balaraman Y, Patel SD, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger Jr JI, Faraone SV, Tsuang MT, Niculescu AB Towards Understanding the Schizophrenia Code: An Expanded Convergent Functional Genomics Approach. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2007 Mar 5;144(2):129-58.

pdf file (1.85 MB)

Niculescu AB. Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry. Psychiatric Genetics. 2006 Dec;16(6):241-4.

pdf file (98 KB)

Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger Jr JI, Edenberg HJ, McBride WJ, and Niculescu AB. Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. The Pharmcogenomics Journal. 2007; 7: 222-56.

pdf file (567 KB)

Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB. PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2006 Sep 5;141B(6):653-62.

pdf file (374 KB)

Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. Striatopallidal regulation of affect in bipolar disorder. Journal of Affective Disorders. 2006 Apr;91(2-3):235-42. Epub 2006 Feb 24.

pdf file (201 KB)

Bertsch B, Ogden CA, Sidhu K, Le-Niculescu H, Kuczenski R, Niculescu AB. Convergent functional genomics: A Bayesian candidate gene identification approach for complex disorders. Methods 2005 Nov;37(3):274-9.

pdf file (171 KB)

Niculescu AB. Genomic studies of mood disorders - the brain as a muscle? Minireview Genome Biology. 2005;6(4):215. Epub 2005 Mar 24. Review.

pdf file (68 KB)

Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R, Niculescu AB. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Molecular Psychiatry. 2004 Nov;9(11):1007-29.

pdf file (2.34 MB)

Lohr JB, Kuczenski R, Niculescu AB. Oxidative Mechanisms and Tardive Dyskinesia. CNS Drugs2003;17(1):47-62.

pdf file (346 KB)

Niculescu AB, Kelsoe JR. Finding Genes for Bipolar Disorder in the Functional Genomics Era: From Convergent Functional Genomics to Phenomics and Back. CNS Spectrums 2002 Mar;7(3): 215-6, 223-6.

pdf file (96 KB)

Stahl SM, Niculescu AB. Molecular and Cellular Biology Research in Psychiatry. Chapter in Psychiatry as a Neuroscience, JJ Lopez-Ibor, W Gaebel, M Maj, N Sartorius (eds.), John Wiley & Sons, Ltd. 2002.

pdf file (4.03 MB)

Niculescu AB, Akiskal HS. Sex hormones, Darwinism, and depression. Arch Gen Psychiatry. 2001 Nov;58(11):1083-4; discussion 1085-6.

pdf file (65 KB)

Niculescu AB, Kelsoe JR. The human genome: genetic testing and animal models. American Journal of Psychiatry. 2001 Oct;158(10):1587.

pdf file (90 KB)

Niculescu AB, Akiskal HS. Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations. Molecular Psychiatry. 2001 Jul;6(4):363-6. Review.

pdf file (121 KB)

Niculescu AB, Kelsoe JR. Convergent functional genomics: application to bipolar disorder. Ann Med. 2001 May;33(4):263-71. Review.

pdf file (943 KB)

Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics. 2000 Nov 9;4(1):83-91.

pdf file (180 KB)

Niculescu AB. The will to live, suicide, and euthanasia. Arch Intern Med. 2000 Jun 12;160(11):1706.

pdf file (334 KB)

Niculescu AB. Prophylactic antidepressant treatment before patients are admitted. Lancet. 2000 Jan 29;355(9201):406-7.

pdf file (610 KB)

Niculescu AB, Chen X, Smeets M, Hengst H, Prives C, Reed SI. Effects of p21 Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication. Molecular and Cellular Biology. 1998 Jan;18(1):629-43.

pdf file (1.36 MB)