Selected Publications

“Look to the genome to rebuild healthcare” -Leroy Hood, Institute for Systems Biology

• R Bhagar , S S Gill , H Le-Niculescu , C Yin , K Roseberry , J Mullen , M Schmitz , E Paul , J Cooke , C Tracy , Z Tracy , A S Gettelfinger , D Battles , M Yard , G Sandusky , A Shekhar , S M Kurian , P Bogdan , A B Niculescu. Next-generation precision medicine for suicidality prevention. Transl Psychiatry. 2024 Sep 6;14(1):362. doi: 10.1038/s41398-024-03071-y.PMID: 39242534
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• Hill MD, Gill SS, Le-Niculescu H, MacKie O, Bhagar R, Roseberry K, Murray OK, Dainton HD, Wolf SK, Shekhar A, Kurian SM, Niculescu AB. Precision Medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics. Molecular Psychiatry. 2024 Feb 8 (2) doi: 10.1038/s41380-024-02433-8 PMID: 38326562
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• R. Bhagar, H. Le-Niculescu, K. Roseberry, K. Kosary, C. Daly, A. Ballew, M. Yard, G. E. Sandusky, A. B. Niculescu. Temporal effects on death by suicide: empirical evidence and possible molecular correlates. Discover Mental Health. 2023 April 3(10) doi: 10.1007/s44192-023-00035-4
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• K. Roseberry, H. Le-Niculescu, D.F Levey, R. Bhagar, K. Soe, J. Rogers, S. Palkowitz, N. Pina, W.A. Anastasiadis, S. S. Gill, S. M. Kurian, A. Shekhar, A. B. Niculescu. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry. 2023  March 7(2) doi: 10.1038/s41380-023-01998-0 PMID: 36878964
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• M. Cheng, K. Roseberry, Y. Choi, L. Quast, M. Gaines, G. Sandusky, J. A. Kline, P. Bogdan, A. B. Niculescu. Polyphenic risk score shows robust predictive ability for long-term future suicidality. Discover Mental Health. 2022  June 13(2) doi: 10.1007/s44192-022-00016-z.
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  • Niculescu Convergent Functional Information for Suicidality Scale (CFI-S)

• Niculescu AB, Le-Niculescu H. Precision medicine in psychiatry: biomarkers to the forefront.   Neuropsychopharmacology. 2022  Jan 47(1):422-423. doi: 10.1038/s41386-021-01183-3. PMID: 34584209
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• Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.  Molecular Psychiatry. 2021 Jul 26(7): 2776-2804. doi: 10.1038/s41380-021-01061-w. Epub Apr 8 2021 PMID: 33828235
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• Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ. Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs.  Molecular Psychiatry. 2020 Aug; 25(8):1651-1672. doi: 10.1038/s41380-019-0602-2. Epub Dec 12 2019 PMID: 31792364.
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• Niculescu AB, Le-Niculescu H, Convergence of recent GWAS data for suicidality with previous blood biomarkers: independent reproducibility using independent methodologies in independent cohorts.  Molecular Psychiatry. 2020 Jan; 25(1): 19-21. doi: 10.1038/s41380-019-0465-6. Epub August 5 2019. PMID: 31383925
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• Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Phalen PL, Mamdani F, Sequeira A, Kurian SM, Niculescu AB. Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs.  Molecular Psychiatry. 2020 May; 25(5): 918-938. doi: 10.1038/s41380-019-0370-z. Epub March 12 2019  PMID: 30862937
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• Supplementary Information - Figures S1-S2 and Tables S2- S4.docx
• Supplementary Information - Detailed Demographics Table S1.docx

• Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, Khan F, Jones T, Judd S, McCormick MA, Wessel AR, Wiliams A, Kurian SM, White FA. Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs.,  Molecular Psychiatry. 2019  Apr; 24(4): 501-522. doi: 10.1038/s41380-018-0345-5. Epub Feb 12 2019 PMID: 30755720
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• Supplementary Information -Figure S1 and Tables S2-S5.docx
• Supplementary Information-Detailed Demographics Table S1.docx

• Brucker KM, Duggan C Roseberry K, Le-Niculescu H, *Niculescu AB,  *Kline JA. Assessing Risk of Future Suicidality in Emergency Department Patients,  Academic Emergency Medicine. 2019 Apr; 26(4): 376-383  2018 Oct 30. doi: 10.1111/acem.13562. Epub Oct 30 2018  PMID: 30375082
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• Supplementary Information Tables S1-S3.docx
• Supplementary Information -Complete Datasets and Analyses.xlsx

• Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR. Precision medicine for suicidality: from universality to subtypes and personalization. Molecular Psychiatry. 2017 Sep;22(9):1250-1273. doi: 10.1038/mp.2017.128. Epub Aug 2017 PMID: 28809398

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• Niculescu AB, Le-Niculescu H. Dissecting Suicidality Using a Combined Genomic and Clinical Approach. Neuropsychopharmacology 2017 Jan; 42(1): 360. doi:10.1038/npp.2016.228. PMID: 27909331
  

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• Rangaraju S, Levey DF, Nho N, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, and Niculescu AB. Mood, Stress and Longevity: Convergence on ANK3. Molecular Psychiatry. 2016 Aug;21(8):1037-49. doi: 10.1038/mp.2016.65. Epub 2016 May 24. PMID: 27217151
  

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• Levey DF, Niculescu EM, Le-Niculescu H, Dainton HD, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry. 2016 Jun;21(6):768-85. doi: 10.1038/mp.2016.31. Epub 2016 Apr 5. PMID: 27046645
  

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• Niculescu AB. A brief proposal for improving clinical trials. Molecular Psychiatry. 2016 Jun;21(6):736-7. doi: 10.1038/mp.2016.42. Epub 2016 Mar 29. PMID: 27021813
  

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• Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, Petrascheck M. Elife. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. eLife 2015 Dec 1;4. pii: e08833. doi: 10.7554 PMID: 26623667
  

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• Niculescu AB , Levey DF, Phalen PL, Le-Niculescu H, Dainton HD ,Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Molecular Psychiatry 2015 20: 1266–1285; doi:10.1038/mp.2015.112; Epub August 18 PMID: 26283638
  

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• Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD, Niculescu AB, Petrascheck M. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell. 2015 Dec;14(6):971-81. doi: 10.1111/acel.12379. Epub 2015 Aug 8
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• Swaminathan S, Koller DL, Foroud T, Edenberg HJ, Xuei X, Niculescu AB 3rd; Bipolar Genome Study (BiGS) Consortium,, Nurnberger JI Jr. J. Characteristics of Bipolar I patients grouped by externalizing disorders. Affect Disord. 2015 Jun 1;178:206-14. doi: 10.1016/j.jad.2015.03.011. Epub 2015 Mar 14. PMID: 25827505
  

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• Nho K, Ramanan VK, Horgusluoglu E, Kim S, Inlow MH, Risacher SL, McDonald BC, Farlow MR, Foroud TM, Gao S, Callahan CM, Hendrie HC, Niculescu AB, Saykin AJ; Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults. Alzheimer’s Disease Neuroimaging Initiative (ADNI). J Alzheimers Dis. 2015;45(4):1197-206. doi: 10.3233/JAD-148009. PMID: 25690665
  

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• Niculescu AB, Levey DF, Le-Niculescu H, Niculescu E, Kurian SM, Salomon, D. Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Molecular Psychiatry2015 Mar;20(3):286-8. doi: 10.1038/mp.2014.180. Epub 2015 Jan 13. PMID: 25582618
  

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• Levey DF., H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu. Genetic Risk Prediction and Neurobiological Understanding of Alcoholism. Translational Psychiatry 2014 May 20;4:e391. doi: 10.1038/tp.2014.29. 2014 Epub May 20. PMID: 24844177

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• Niculescu AB. DISCovery in psychiatric genetics. Molecular Psychiatry 2014 Feb;19(2):145. doi: 10.1038/mp.2013.176. Epub 2013 Dec 17. PMID: 24342993

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• Niculescu AB. Convergent functional genomics of stem cell-derived cells. Translational Psychiatry. 2013 Sep 10;3:e305. doi: 10.1038/tp.2013.78. PMID: 24022510

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• Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry  2013 Dec;18(12):1249-64. doi: 10.1038/mp.2013.95. Epub 2013 Aug 20.  PMID: 23958961

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• Niculescu AB. Convergent Functional Genomics of Psychiatric Disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2013 Oct;162B(7):587-94. doi: 10.1002/ajmg.b.32163. 2013 Epub May 31.

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• Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O’Donovan M, Niculescu AB. Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction. Molecular Psychiatry 2012 Sep;17(9):887-905. doi: 10.1038/mp.2012.37. Epub 2012 May 15.

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• Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M , Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA and Niculescu AB.Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Translational Psychiatry 2011. Epub 2011 May 24.

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• Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD , Bowker D, Gupta J, Bell R, Edenberg HJ , Tsuang MT, Kuczenski R, Geyer MA, Rodd Z, Niculescu AB. Convergent Functional Genomic Studies of Omega-3 Fatty Acids in Stress Reactivity, Bipolar Disorder and Alcoholism. Translational Psychiatry 2011. Epub 2011 April 26.

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• Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger Jr JI, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR and Niculescu AB. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry 2011 February;16, 37–58. Epub 2009 Nov 24.

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• Le-Niculescu H, Patel SD, Niculescu AB. Convergent Integration of Animal Model and Human Studies of
  Bipolar Disorder (manic-depressive illness). Current Opinion in Pharmacology 2010, 10:594–600

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• Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB.
  Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B
  (Neuropsychiatric Genetics). 2010. Jun 5;153B(4):850-77. Epub April 9.

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• Niculescu AB, Le-Niculescu H. The P-Value Illusion: How to Improve (Psychiatric) Genetic Studies.
  American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2010. Jun 5;153B(4):847-9

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• Niculescu AB, Hulvershorn L. Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri-Dimensional Approach. Psychopharm Review. 2010. 45(2): 9-16.

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• Niculescu AB, Le-Niculescu H. Convergent Functional Genomics: What We Have Learned and Can Learn About Genes, Pathways, and Mechanisms. Neuropsychopharmacology. 2010 Jan;35(1):355-6.

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• Caligiuri MP, Teulings HL, Dean CE, Niculescu AB 3rd, Lohr JB. Handwriting movement kinematics for
  quantifying extrapyramidal side effects in patients treated with atypical antipsychotics. Psychiatry Res. 2010
  May 15;177(1-2):77-83.

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• McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT. Evidence for genetic association of RORB with bipolar disorder. BMC Psychiatry. 2009 Nov 12;9:70.

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• Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone. Human Movement Science. 2009 Oct;28(5):633-42. Epub 2009 Aug 18.

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• Niculescu AB, Schork NJ, Salomon DR. Mindscape: A convergent perspective on life, mind, consciousness and happiness. Journal of Affective Disorders. 2010 Jun;123(1-3):1-8.

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• Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger Jr JI, and Niculescu AB. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181.

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• Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger Jr JI, Niculescu AB. Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics. Molecular Psychiatry. 2009 Feb;14(2):156-74. Epub 2008 Feb 26.

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• Liu L, Foroud R, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon E, Kelsoe J, Lawson W, MacKinnon D, McInnis M, McMahon F, Murphy D, Rice J, Scheftner W, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger Jr JI. Evidence of association between brain-derived neurotrophic factor (BDNF) gene and bipolar disorder. Psychiatric Genetics. 2008 Dec;18(6):267-74.

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• Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S , Tan J, Rodd ZA, Paulus M, Geyer M, Edenberg HJ, Glatt SJ, Faraone SV, , Nurnberger JI, Kuczenski R, Tsuang MT and Niculescu AB. Phenomic, convergent functional genomic and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2008 Mar 5;147(2):134-166.

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• Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM, Salomon DR, Tsuang MT, Nurnberger Jr JI, Niculescu AB. Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers. Neuroscience Biobehavioral Reviews Rev. 2007;31(6):897-903. Epub 2007 Jun 3. Review.

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• Le-Niculescu H, Balaraman Y, Patel SD, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger Jr JI, Faraone SV, Tsuang MT, Niculescu AB Towards Understanding the Schizophrenia Code: An Expanded Convergent Functional Genomics Approach. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2007 Mar 5;144(2):129-58.

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• Niculescu AB. Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry. Psychiatric Genetics. 2006 Dec;16(6):241-4.

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• Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger Jr JI, Edenberg HJ, McBride WJ, and Niculescu AB. Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. The Pharmcogenomics Journal. 2007; 7: 222-56.

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• Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB. PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2006 Sep 5;141B(6):653-62.

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• Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB. Striatopallidal regulation of affect in bipolar disorder. Journal of Affective Disorders. 2006 Apr;91(2-3):235-42. Epub 2006 Feb 24.

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• Bertsch B, Ogden CA, Sidhu K, Le-Niculescu H, Kuczenski R, Niculescu AB. Convergent functional genomics: A Bayesian candidate gene identification approach for complex disorders. Methods 2005 Nov;37(3):274-9.

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• Niculescu AB. Genomic studies of mood disorders - the brain as a muscle? Minireview Genome Biology. 2005;6(4):215. Epub 2005 Mar 24. Review.

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• Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R, Niculescu AB. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Molecular Psychiatry. 2004 Nov;9(11):1007-29.

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• Lohr JB, Kuczenski R, Niculescu AB. Oxidative Mechanisms and Tardive Dyskinesia. CNS Drugs2003;17(1):47-62.

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• Niculescu AB, Kelsoe JR. Finding Genes for Bipolar Disorder in the Functional Genomics Era: From Convergent Functional Genomics to Phenomics and Back. CNS Spectrums 2002 Mar;7(3): 215-6, 223-6.

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• Stahl SM, Niculescu AB. Molecular and Cellular Biology Research in Psychiatry. Chapter in Psychiatry as a Neuroscience, JJ Lopez-Ibor, W Gaebel, M Maj, N Sartorius (eds.), John Wiley & Sons, Ltd. 2002.

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• Niculescu AB, Akiskal HS. Sex hormones, Darwinism, and depression. Arch Gen Psychiatry. 2001 Nov;58(11):1083-4; discussion 1085-6.

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• Niculescu AB, Kelsoe JR. The human genome: genetic testing and animal models. American Journal of Psychiatry. 2001 Oct;158(10):1587.

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• Niculescu AB, Akiskal HS. Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations. Molecular Psychiatry. 2001 Jul;6(4):363-6. Review.

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• Niculescu AB, Kelsoe JR. Convergent functional genomics: application to bipolar disorder. Ann Med. 2001 May;33(4):263-71. Review.

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• Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics. 2000 Nov 9;4(1):83-91.

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• Niculescu AB. The will to live, suicide, and euthanasia. Arch Intern Med. 2000 Jun 12;160(11):1706.

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• Niculescu AB. Prophylactic antidepressant treatment before patients are admitted. Lancet. 2000 Jan 29;355(9201):406-7.

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• Niculescu AB, Chen X , Smeets M, Hengst H, Prives C, Reed SI. Effects of p21 Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication. Molecular and Cellular Biology. 1998 Jan;18(1):629-43.

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