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Prioritizing Candidate Genes and Biomarkers for Psychiatric Disorders using Convergent Functional Genomics

Mood, stress and longevity: convergence on ANK3.

Rangaraju S, Levey DF, Nho N, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, and Niculescu AB. Mood, Stress and Longevity: Convergence on ANK3. Molecular Psychiatry 2016 May 24 doi: 10.1038/mp.2016.65.

Longevity Pyramid

Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Levey DF, Niculescu EM, Le-Niculescu H, Dainton HD, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016 April 5 doi: 10.1038/mp.2016.31.

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Niculescu AB , Levey DF, Phalen PL, Le-Niculescu H, Dainton HD ,Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Molecular Psychiatry 2015 Epub August 18.

Genetic Risk Prediction and Neurobiological Understanding of Alcoholism.

D.F. Levey, H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu. Translational Psychiatry. Epub 2014 May 20.

Top candidate genes for alcoholism.

Discovery and validation of blood biomarkers for suicidality.

Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Molecular Psychiatry. Epub 2013 August 20.

Top candidate blood biomarkers for suicidality.


Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction.

Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O'Donovan M, Niculescu AB. Molecular Psychiatry. Epub 2012 May 15.

Top candidate genes for schizophrenia.


Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.

Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M , Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA and Niculescu AB.Translational Psychiatry 2011. Epub 2011 May 24

Top candidate genes for anxiety.


Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism

Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD , Bowker D, Gupta J, Bell R, Edenberg HJ , Tsuang MT , Kuczenski R, Geyer MA, Rodd Z, Niculescu AB. Translational Psychiatry2011. Epub April 26.

 

Top candidate genes changed in DBP knockout (KO) stressed (ST) mice on high- vs low-docosahexaenoic acid (DHA) diet. (a) Female mice and (b) Male mice


Mindscape: A convergent perspective on life, mind, consciousness and happiness.

Niculescu AB, Schork NJ, Salomon DR. Journal of Affective Disorders. 2010 Jun;123(1-3):1-8.

 

Genetic heterogeneity and complexity.


Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics.

Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2010 Jun 5;153B(4):850-77.

 

Top bipolar candidate genes.


Identification of blood biomarkers for psychosis using convergent functional genomics

SM Kurian, H Le-Niculescu, SD Patel, D Bertram, J Davis, C Dike, N Yehyawi, P Lysaker, J Dustin, M Caligiuri, J Lohr, DK Lahiri, JI Nurnberger Jr, SV Faraone, MA Geyer, MT Tsuang, NJ Schork, DR Salomon and AB Niculescu. Molecular Psychiatry (2009), 1–22

 

Top blood candidate biomarker genes for (a) hallucinations and (b) delusions.
The CFG lines of evidence scoring are depicted on the right side of the pyramid.


Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms

H. Le-Niculescu, S.D. Patel, M. Bhat, R. Kuczenski, S.V. Faraone, M.T. Tsuang, F.J. McMahon, N.J. Schork, J.I. Nurnberger Jr., and A.B. Niculescu III. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181.

 

Top Candidate Genes for Bipolar Disorder Identified by CFG of GWAS data.


Identifying blood biomarkers for mood disorders using convergent functional genomics

H. Le-Niculescu, S. M. Kurian , N. Yehyawi, C. Dike, S.D. Patel, H.J. Edenberg, M. T. Tsuang, D. R. Salomon, J. I. Nurnberger Jr , A. B. Niculescu. Molecular Psychiatry. 2009 Feb;14(2):156-74

 

Top Blood Candidate Biomarker Genes for Mood State.


Phenomic, convergent functional genomic and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism

Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S , Tan J, Rodd ZA, Paulus M, Geyer M, Edenberg HJ, Glatt SJ, Faraone SV, , Nurnberger JI, Kuczenski R, Tsuang MT and Niculescu AB. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2008 Mar 5;147(2):134-166.

 

Top candidate genes. a) DBP KO NST; b) DBP KO ST.


Towards Understanding the Schizophrenia Code: An Expanded Convergent Functional Genomics Approach.

Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI Jr, Faraone SV, Tsuang MT, Niculescu AB. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2007 Mar 5;144(2):129-58

Top Candidate Genes Identified by CFG for Schizophrenia


Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach.

Z.A.Rodd, B.A.Bertsch, W.N.Strother, H.Le-Niculescu, Y.Balaraman, E.Hayden, R.E.Jerome, L.Lumeng, Ji. Nurnberger Jr., H.J.Edenberg, W.J.McBride, and A.B.Niculescu. The Pharmcogenomics Journal. 2007; 7: 222-56

 

Top Candidate Genes Identified by CFG for Alcoholism


Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.

Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R, Niculescu AB. Molecular Psychiatry. 2004; 9:1007-1029

Top Candidate Genes Identified by CFG for Bipolar Disorder